![Low hematocrit and hemoglobin with chronic kidney disease](https://loka.nahovitsyn.com/38.jpg)
A variety of diseases, such as leukemia and myelofibrosis, can cause anemia by affecting blood production in your bone marrow.
![low hematocrit and hemoglobin with chronic kidney disease low hematocrit and hemoglobin with chronic kidney disease](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/990069/7197612/gr1.jpg)
Hemoglobin enables red blood cells to carry oxygen from your lungs to all parts of your body and to carry carbon dioxide from other parts of the body to your lungs to be exhaled. Red blood cells contain hemoglobin - an iron-rich protein that gives blood its red color. Your body makes three types of blood cells - white blood cells to fight infection, platelets to help your blood clot, and red blood cells to carry oxygen from your lungs to the rest of your body and carbon dioxide from the body back to the lungs. Bleeding causes you to lose red blood cells more quickly than they can be replaced.Your body doesn't make enough red blood cells.Anemia occurs when your blood doesn't have enough red blood cells.
![low hematocrit and hemoglobin with chronic kidney disease low hematocrit and hemoglobin with chronic kidney disease](https://i.ytimg.com/vi/6NgP-pCqpeU/mqdefault.jpg)
The effect was strong and significant among white, but not black, children.Īnemia Chronic kidney disease Hemoglobin Vitamin D.Request an Appointment at Mayo Clinic CausesĪnemia can be due to a condition present at birth (congenital) or to a condition you develop (acquired). The data support our hypothesis that vitamin D insufficiency/deficiency increases the odds of anemia in children with CKD. The association between vitamin D status and anemia was not significant in black children.
![low hematocrit and hemoglobin with chronic kidney disease low hematocrit and hemoglobin with chronic kidney disease](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/1036537/7591763/gr1.gif)
Stratified by race, the odds of being anemic was 2.39 times higher (95% CI, 1.41-4.05, p = 0.001) in vitamin D insufficient/deficient vs vitamin D sufficient white children.
![low hematocrit and hemoglobin with chronic kidney disease low hematocrit and hemoglobin with chronic kidney disease](https://europepmc.org/articles/PMC7062209/bin/ASN.2019020213f1.jpg)
In the overall cohort, the odds of being anemic was 1.9 times higher (95% CI, 1.22-3.04, p < 0.01) in vitamin D insufficient/deficient vs sufficient children, when adjusting for covariates (age, sex, race, body mass index (BMI), iohexol GFR (iGFR), erythropoietin stimulation agent (ESA) use, iron supplementation use, and underlying cause of CKD). Of those who were vitamin D insufficient/deficient, 95 (28.44%) were anemic. Overall 334 (57.59%) children were vitamin D insufficient/deficient and 137 (23.62%) were anemic. Anemia was defined as hemoglobin < 5th percentile for age and sex. The cross-sectional associations between 25OHD and hemoglobin (g/dL) and anemia were assessed. This association has not been explored in children with CKD.Ĭhildren aged 1-16 enrolled in the Chronic Kidney Disease in Children (CKiD) study with mild to moderate kidney dysfunction, and with 25OHD measured at baseline (n = 580), were included in the analysis. It has been associated with an increased risk for anemia in both healthy US children and in adults with CKD. 25-Hydroxyvitamin D (25OHD) deficiency is common in children with chronic kidney disease (CKD).
![Low hematocrit and hemoglobin with chronic kidney disease](https://loka.nahovitsyn.com/38.jpg)